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D , Heatmaps of differential gene expression in peritumor astrocytes related to top synaptic function, middle astrocyte reactivity, and bottom mature astrocyte markers. Future studies should aim to identify the signaling mechanisms that drive astrocyte maturation, as aberrations in astrocyte maturation could contribute to dysfunction in neural circuits and ultimately neurodevelopmental disorders. Given the higher variability of human data caused by greater genetic and environmental diversity compared with laboratory mice, future studies with large sample sizes will further expand our understanding of astrocyte aging in humans. We specifically identified a widespread reduction of astrocyte receptor genes, which may limit their ability to sense and respond to their environment. To assess the changes associated with astrocyte maturation, we analyzed GO of upregulated and downregulated astrocyte maturation genes using Metascape see Extended Data Fig.